Defining Yourself: Tolerance Development in the Immune System

Defining yourself: tolerance development in the immune system.

The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals.

The mucosal immune system is exposed to a range of antigens associated with pathogens, to which it must mount active immune responses. However, it is also exposed to a large number of harmless antigens associated with food and with commensal microbial flora, to which expression of active, inflammatory immune responses to these antigens is undesirable. The mucosal immune system must contain mach...

Fetal and Neonatal Immune System Development and Failure

ZUSAMEN-FASSUNG:  Die oben angefuerte Erlaeuterung und Dis­kussion umfasst (I)- normale Entwicklung ein­zelner Hauptkomponente des menschlichen Immunmechanismus, ( 2) Faktoren, die moegli­cherweise fetalen Immunsystem aktivieren, (3) Faktoren, welche die Entwicklung des Immun­systems stoeren koennen.  REFERENCES 

Development of the Immune System

The development of immune defense mechanisms begins early during fetal life but is not yet completed at birth. The earliest hematopoietic stem cells, which give rise to the lymphocytic and myelomonocytic cell lines, appear between the fourth and eight weeks postconception. T cells, responsible for cellular immune defense mechanisms, are first detectable at 12 weeks and seem to acquire their fun...

Rejection and Tolerance The Innate Immune System in Allograft